Cefoperazone Molecular Weight, Sourcing Realities, and Why It Matters on the Plant Floor

If you’re double-checking cefoperazone molecular weight for a procurement spreadsheet, you’re not alone. In fact, it’s one of the first fields QC teams validate when they onboard a new batch of Cefoperazone Acid (CAS 58739-66-5). To be honest, numbers anchor everything: stoichiometry in synthesis, HPLC calibration, even logistics labels. And yes, small variations (salt vs. acid) matter more than people think.

Quick technical snapshot (acid vs. sodium salt)

In routine purchasing and QA paperwork, you’ll typically see: - Acid (free form): cefoperazone molecular weight ≈ 645.6 g/mol (typical literature value). - Sodium salt (anhydrous): cefoperazone molecular weight ≈ 667.6 g/mol. Real-world use may vary with hydration state and analytical reference standards. Always match the CoA.

Product specification (Cefoperazone Acid, CAS 58739-66-5)

Where it’s used, and why the number matters

Cefoperazone Acid is the workhorse intermediate for producing Cefoperazone Sodium—valued for strong anti-pseudomonal coverage in serious infections. R&D groups, API manufacturers, and some CMOs rely on accurate mass for stoichiometric control, salt formation, and assay calculations. A wrong mass input can skew yield predictions and even purge decisions. Many customers say the difference between acid and sodium paperwork tripped them up at least once.

Process flow (simplified)

• Materials: cephalosporin nucleus, activated acyl side chains, coupling reagents, controlled solvents.
• Methods: side-chain coupling → deprotection/neutralization → controlled crystallization → filtration and drying.
• Testing: HPLC related substances, residual solvents (GC), water (KF), ID by IR/NMR, potency vs. reference standard.
• Compliance: USP/EP aligned specs; ISO 9001 QMS; CoA and MSDS supplied; DMF support on request.
• Storage/Service life: cool, dry, light-protected; typical shelf life 24 months, real-world stability depends on humidity controls.

Industry trend check

Third-gen cephalosporins aren’t the flashiest growth story, but demand is steady—particularly in hospital injectables. Procurement teams prioritize consistent assay, impurity profiles, and transparent change control. Surprisingly, buyers tell me freight predictability and batch traceability now rank as high as price.

Vendor comparison (real-world, indicative)

Customization options

• Impurity profile tightening (e.g., single impurity ≤ 0.20%).
• Alternate solvent systems and residual solvent specs.
• Stability/retest protocol adaptation to local regulatory preferences.
• Customized pack sizes and tamper-evident liners.

Case study: reducing batch-to-batch drift

A mid-size EU sterile manufacturer reported 1–2% assay drift across quarters. After switching to Hejia’s material and harmonizing the calculation basis (acid form mass vs. sodium salt), their HPLC assay tightened to 99.1% ±0.3% over six lots, with moisture consistently ≤0.7%. Small change, big relief for validation. They told me the clarifying note on the mass basis—yes, that simple—cut deviations in half.

Bottom line: the number on your SDS matters. Keep your cefoperazone molecular weight aligned with the correct form, and your yields, labels, and filings tend to behave.

References

1. USP–NF Monograph: Cefoperazone Sodium (assay and ID guidance; molecular mass basis).
2. European Pharmacopoeia (Ph. Eur.): Cefoperazone Sodium Monograph, current edition.
3. PubChem Compound Summary: Cefoperazone; commonly cited molecular weights for acid vs. sodium forms.
4. FDA Orange Book/Agency files: Reference standards and labeling conventions for cephalosporins.